Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.47 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3289690 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL10492812 | 0.90 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL239487 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064710 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064712 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL31272367 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL28138648 | 0.83 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL226489 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL437150 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL6429247 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1963678-B | Method for limiting pattern | AIR PROD & CHEM | 2012-10-10 | — | — | CN | claimed |
| CN-101857825-B | Composition for stripping and cleaning and use thereof | AIR PROD & CHEM | 2012-09-19 | — | — | CN | claimed |
| CN-1715389-B | Composition for cleaning and cleansing and use thereof | AIR PROD & CHEM | 2010-10-27 | — | — | CN | claimed |
| CN-101857825-A | Be used to the composition and use thereof removing and clean | AIR PROD & CHEM | 2010-10-13 | — | — | CN | claimed |
| CN-1963678-A | Method for limiting pattern | AIR PROD & CHEM (US) | 2007-05-16 | — | — | CN | claimed |
| US-6841061-B1 | Antigelling agent for hydrocarbon mixture containing conjugated diene and method of preventing clogging of apparatus for separating and purifying the mixture | ZEON CORPORATION (JP) | 2005-01-11 | — | — | US | disclosed |
| EP-1184444-A1 | ANTIGELLING AGENT FOR HYDROCARBON MIXTURE CONTAINING CONJUGATED DIENE AND METHOD OF PREVENTING CLOGGING OF APPARATUS FOR SEPARATING AND PURIFYING THE MIXTURE | Nippon Zeon Co., Ltd. (JP) | 2002-03-06 | — | — | EP | disclosed |