Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.47 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HMGCR | P04035 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6313398 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL10492812 | 0.90 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL239487 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064710 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL2064712 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL31272367 | 0.84 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL28138648 | 0.83 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL226489 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL437150 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR | |
| Citric Acid SCHEMBL6429247 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7018454-B2 | Ink jet ink and recording material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2006-03-28 | — | — | US | claimed |
| EP-1572817-A1 | INK-JET INK AND RECORDING MATERIAL | Ciba SC Holding AG (CH) | 2005-09-14 | — | — | EP | claimed |
| WO-2004056931-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2004-07-08 | — | — | WO | claimed |
| US-20040126510-A1 | Ink jet ink and recording material | CIBA SPECIALTY CHEMICALS CORP. | 2004-07-01 | — | — | US | claimed |
| US-6599326-B1 | Composition having reduced loss of brightness and enhanced resistance to yellowing which comprises chemical paper which may still contain traces of lignin and N,N-dialkylhydroxylamine or derivative or salt thereof | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-07-29 | — | — | US | claimed |
| EP-1718271-B1 | STABILIZED BODY CARE PRODUCTS, HOUSEHOLD PRODUCTS | BASF SE (DE) | 2014-10-08 | — | — | EP | disclosed |
| US-7718096-B2 | Stabilized electrochromic media | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2010-05-18 | — | — | US | disclosed |
| US-7618618-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORP. (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618644-B2 | Sterically hindered amine salts having an N-(alkoxy, cycloalkoxy or aralkoxy)2,2,6,6-tetraalkylsubstituted piperidine moiety; discoloration inhibition, colorfastness | CIBA SPECIALTY CHEMICALS CORP. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20090074681-A1 | Sterically hindered amine salts having an N-(alkoxy, cycloalkoxy or aralkoxy)2,2,6,6-tetraalkylsubstituted piperidine moiety; discoloration inhibition, colorfastness | LUPIA JOSEPH A | 2009-03-19 | — | — | US | disclosed |
| US-7429545-B2 | Stabilized body care products, household products, textiles and fabrics | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-09-30 | — | — | US | disclosed |
| EP-1896550-A1 | STABILIZED ELECTROCHROMIC MEDIA | Ciba Specialty Chemicals Holding Inc. (CH) | 2008-03-12 | — | — | EP | disclosed |
| US-6599326-B1 | Composition having reduced loss of brightness and enhanced resistance to yellowing which comprises chemical paper which may still contain traces of lignin and N,N-dialkylhydroxylamine or derivative or salt thereof | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-07-29 | — | — | US | disclosed |
| US-20020174964-A1 | Inhibition of pulp and paper yellowing using hydroxylamines and other coadditives | SELTZER RAYMOND (US) | 2002-11-28 | — | — | US | disclosed |
| US-20020088574-A1 | INHIBITION OF PULP AND PAPER YELLOWING USING HYDROXYLAMINES AND OTHER COADDITIVES | CIBA SPECIALTY CHEMICALS CORP. | 2002-07-11 | — | — | US | disclosed |
| CN-1355835-A | Antigelling agent for hydrocarbon mixture containing conjugated and method for preventing clogging of apparatus for separating and purifying mixture | NIPPON ZEON CO (JP) | 2002-06-26 | — | — | CN | disclosed |
| EP-1184444-A1 | ANTIGELLING AGENT FOR HYDROCARBON MIXTURE CONTAINING CONJUGATED DIENE AND METHOD OF PREVENTING CLOGGING OF APPARATUS FOR SEPARATING AND PURIFYING THE MIXTURE | Nippon Zeon Co., Ltd. (JP) | 2002-03-06 | — | — | EP | disclosed |
| EP-1131483-A1 | INHIBITION OF PULP AND PAPER YELLOWING USING HYDROXYLAMINES AND OTHER COADDITIVES | Ciba SC Holding AG (CH) | 2001-09-12 | — | — | EP | disclosed |
| EP-1061059-A1 | POLYMERIZATION-INHIBITING COMPOSITION, POLYMERIZATION INHIBITOR AND METHOD FOR INHIBITING POLYMERIZATION | NIPPON ZEON CO., LTD. (JP) | 2000-12-20 | — | — | EP | disclosed |
| WO-2000024963-A1 | INHIBITION OF PULP AND PAPER YELLOWING USING HYDROXYLAMINES AND OTHER COADDITIVES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2000-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090074681-A1 | Sterically hindered amine salts having an N-(alkoxy, cycloalkoxy or aralkoxy)2,2,6,6-tetraalkylsubstituted piperidine moiety; discoloration inhibition, colorfastness | DEK, CUTA, ANKK1 | MEN1 4734/4885ESR1 4799/4885ESR2 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.