Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313704 | 0.83 | IGF1R (0.59) | IGF1RPIK3CAS1PR1 | |
| Ammonia Solution, Strong SCHEMBL6312316 | 0.76 | ADORA1 (0.47) | ADORA1IGF1RPIK3CAADORA2AMTOR | |
| SCHEMBL5885193 | 0.72 | ADORA1 (0.43) | ADORA1IGF1RPIK3CAADORA2AMTOR | |
| SCHEMBL856589 | 0.72 | ADORA1 (0.58) | ADORA1ADORA2ADHFR | |
| SCHEMBL10327965 | 0.69 | PIK3CA (0.74) | PIK3CAMTORAKT1 | |
| SCHEMBL27930047 | 0.69 | PRKDC (0.50) | ALDH1A1LMNAKDM4EHTTGAA | |
| SCHEMBL10328148 | 0.66 | PIK3CA (0.80) | PIK3CAMTORPIK3CG | |
| SCHEMBL6319164 | 0.66 | PIK3CA (0.58) | IGF1RPIK3CAKDM4ESMN1; SMN2 | |
| SCHEMBL18335242 | 0.66 | DHFR (0.56) | ADORA1PIK3CAADORA2AMTORAKT1 | |
| SCHEMBL5405504 | 0.66 | PRKCZ (0.55) | ADORA1PIK3CAADORA2ACCKARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | claimed |
| US-20040063705-A1 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. | 2004-04-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063705-A1 | Substituted pyrimidinyl derivatives and methods of use | DPYD, TYMP, TPMT | ADORA1 677/4885IGF1R 4054/4885PIK3CA 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.