Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14118735 | 0.89 | ALDH1A1 (0.50) | LMNAKDM4EALDH1A1 | |
| SCHEMBL28274592 | 0.82 | LMNA (0.59) | LMNAKDM4ECHRM1ALDH1A1P2RX4 | |
| SCHEMBL30421484 | 0.82 | POLB (0.61) | LMNAKDM4EALDH1A1MAOB | |
| SCHEMBL30747701 | 0.82 | LMNA (0.59) | LMNAKDM4ECHRM1ALDH1A1P2RX4 | |
| SCHEMBL398161 | 0.82 | POLB (0.61) | LMNAKDM4EALDH1A1MAOB | |
| SCHEMBL7545236 | 0.82 | LMNA (0.59) | LMNAKDM4ECHRM1ALDH1A1P2RX4 | |
| SCHEMBL28227903 | 0.82 | LMNA (0.63) | LMNAKDM4ECHRM1ALDH1A1P2RX4 | |
| SCHEMBL4769816 | 0.82 | LMNA (0.63) | LMNAKDM4ECHRM1ALDH1A1P2RX4 | |
| SCHEMBL30309433 | 0.81 | KDM4E (0.61) | LMNAKDM4ECHRM1 | |
| SCHEMBL5100563 | 0.81 | KDM4E (0.61) | LMNAKDM4ECHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6872718-B1 | Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-03-29 | — | — | US | disclosed |
| EP-1211253-B1 | TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-10-13 | — | — | EP | disclosed |