Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | F11 | P03951 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314671 | 0.93 | EGFR (0.61) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6308080 | 0.92 | F11 (0.57) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL7550360 | 0.91 | EGFR (0.53) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6308755 | 0.91 | EGFR (0.56) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6315683 | 0.89 | EGFR (0.69) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6308934 | 0.89 | EGFR (0.64) | EGFRPOLBRXFP1MAPTABCC1 | |
| SCHEMBL6308357 | 0.88 | EGFR (0.59) | EGFRPOLBRXFP1MAPTABCC1 | |
| SCHEMBL6314802 | 0.86 | EGFR (0.83) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6314890 | 0.85 | EGFR (0.86) | EGFRPOLBRXFP1ALDH1A1MAPT | |
| SCHEMBL6314294 | 0.85 | EGFR (0.59) | EGFRPOLBRXFP1MAPTABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |