Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308920 | 0.92 | EGFR (0.51) | EGFRABCC1POLBSMN1; SMN2LMNA | |
| SCHEMBL6308357 | 0.90 | EGFR (0.59) | EGFRABCC1POLBSMN1; SMN2MEN1 | |
| SCHEMBL6314616 | 0.86 | SMN1; SMN2 (0.67) | ABCC1POLBSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6313852 | 0.85 | EGFR (0.64) | EGFRABCC1POLBSMN1; SMN2LMNA | |
| SCHEMBL7550360 | 0.85 | EGFR (0.53) | EGFRABCC1POLBSMN1; SMN2LMNA | |
| SCHEMBL6309009 | 0.83 | SMN1; SMN2 (0.51) | ABCC1POLBSMN1; SMN2LMNAMAPT | |
| SCHEMBL6314671 | 0.83 | EGFR (0.61) | EGFRABCC1POLBTP53MAPT | |
| SCHEMBL6308934 | 0.83 | EGFR (0.64) | EGFRABCC1POLBTP53MAPT | |
| SCHEMBL6308755 | 0.83 | EGFR (0.56) | EGFRABCC1POLBMEN1KMT2A | |
| SCHEMBL6315683 | 0.83 | EGFR (0.69) | EGFRPOLBMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |