Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | CASR | P41180 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | F11 | P03951 | 7/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314431 | 0.88 | MEN1 (0.67) | MAPTCASRTP53ALDH1A1MEN1 | |
| SCHEMBL6314002 | 0.88 | CASR (0.65) | MAPTCASRTP53ALDH1A1MEN1 | |
| SCHEMBL6309029 | 0.88 | CASR (0.68) | MAPTCASRALDH1A1KMT2AGAA | |
| SCHEMBL6308923 | 0.86 | MAPT (0.46) | MAPTTP53ALDH1A1MEN1KMT2A | |
| SCHEMBL6314229 | 0.84 | EGFR (0.55) | MAPTCASRTP53MEN1KMT2A | |
| SCHEMBL6306215 | 0.84 | EGFR (0.64) | MAPTTP53KMT2ARXFP1SMN1; SMN2 | |
| SCHEMBL6307999 | 0.84 | ALDH1A1 (0.69) | MAPTALDH1A1MEN1KMT2AF11 | |
| SCHEMBL6306796 | 0.83 | F11 (0.61) | MAPTCASRALDH1A1MEN1KMT2A | |
| SCHEMBL6308188 | 0.81 | GHSR (0.54) | MAPTCASRGAAF11EGFR | |
| SCHEMBL6306167 | 0.81 | KMT2A (0.63) | MAPTCASRTP53ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |