Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314616 | 0.89 | SMN1; SMN2 (0.67) | POLBSMN1; SMN2TP53ALDH1A1ABCC1 | |
| SCHEMBL6308756 | 0.88 | POLB (0.56) | POLBSMN1; SMN2TP53GAAALDH1A1 | |
| SCHEMBL6308495 | 0.87 | F11 (0.59) | POLBSMN1; SMN2TP53GAAALDH1A1 | |
| SCHEMBL6315757 | 0.86 | POLB (0.57) | POLBSMN1; SMN2TP53GAAABCC1 | |
| SCHEMBL6308357 | 0.86 | EGFR (0.59) | POLBSMN1; SMN2TP53GAAABCC1 | |
| SCHEMBL6307999 | 0.85 | ALDH1A1 (0.69) | POLBSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL6309193 | 0.85 | F11 (0.62) | POLBSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL6309730 | 0.84 | ALDH1A1 (0.59) | POLBSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL6313886 | 0.84 | ALDH1A1 (0.57) | POLBSMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL6306167 | 0.83 | KMT2A (0.63) | POLBSMN1; SMN2TP53GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890930-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |
| EP-1216235-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023365-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |