Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877994 | 0.85 | POLB (0.44) | ATMALDH1A1ABCC1NPSR1HTT | |
| SCHEMBL5877389 | 0.85 | NPC1 (0.46) | ATMLMNAPOLBTSHRSMN1; SMN2 | |
| SCHEMBL5877726 | 0.85 | ATM (0.43) | ATMALDH1A1ABCC1LMNAPLA2G1B | |
| SCHEMBL5877496 | 0.83 | TSHR (0.48) | ATMALDH1A1NPSR1HTTLMNA | |
| SCHEMBL5877050 | 0.82 | ABCC1 (0.62) | ALDH1A1ABCC1NPSR1LMNAPLA2G1B | |
| SCHEMBL5878320 | 0.80 | ABCC1 (0.62) | ALDH1A1ABCC1NPSR1LMNATDP1 | |
| SCHEMBL6315006 | 0.79 | ATM (0.63) | ATMALDH1A1NPSR1HTTUSP2 | |
| SCHEMBL5877140 | 0.79 | ALDH1A1 (0.46) | ATMALDH1A1ABCC1NPSR1HIF1A | |
| SCHEMBL5877289 | 0.78 | KDM4E (0.59) | ALDH1A1LMNAPLA2G1BATG4BPOLB | |
| SCHEMBL5877288 | 0.78 | KDM4E (0.59) | ALDH1A1LMNAPLA2G1BATG4BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |