Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | UBE2I | P63279 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6315631 | 0.90 | SMN1; SMN2 (0.50) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6318943 | 0.88 | ADORA2A (0.60) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6317749 | 0.88 | ADORA2A (0.60) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6316308 | 0.87 | ALDH1A1 (0.60) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6323008 | 0.85 | CA1 (0.52) | ADORA2AADORA1ADORA3ADORA2BMEN1 | |
| SCHEMBL6317734 | 0.85 | SMN1; SMN2 (0.51) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6315566 | 0.85 | MLYCD (0.47) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6318351 | 0.84 | PTPN22 (0.46) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6316611 | 0.84 | RAB9A (0.48) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 | |
| SCHEMBL6316877 | 0.82 | ADORA2A (0.57) | ADORA2AADORA1ADORA3ADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | claimed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
| EP-1435948-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003013517-A1 | AMINOISOXAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | ADORA2A 1101/4885ADORA1 1592/4885ADORA3 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.