Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6323905 | 0.88 | NPC1 (0.52) | ALDH1A1TP53MAPTLMNAHPGD | |
| SCHEMBL6316520 | 0.86 | MAPT (0.52) | ALDH1A1TSHRTP53MAPTLMNA | |
| SCHEMBL6316658 | 0.85 | TAS1R3 (0.53) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL6316978 | 0.85 | TAS1R3 (0.52) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL6321897 | 0.83 | SMN1; SMN2 (0.47) | ALDH1A1LMNAPKMHPGDHTT | |
| SCHEMBL6316160 | 0.83 | MAOB (0.46) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL6324368 | 0.82 | MAPT (0.44) | ALDH1A1TSHRMAPTROCK2LMNA | |
| SCHEMBL6317699 | 0.81 | ALDH1A1 (0.45) | ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL6317197 | 0.81 | LMNA (0.44) | ALDH1A1TSHRTP53MAPTROCK2 | |
| SCHEMBL6315275 | 0.81 | NPC1 (0.48) | ALDH1A1TSHRMAPTROCK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | ALDH1A1 4444/4885TSHR 3971/4885NPSR1 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.