Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.87 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | PTPRC | P08575 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TNKS | O95271 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751583 | 0.93 | PTGS2 (1.00) | PTGS2ALOX5PTPRCRAB9AKDM4E | |
| SCHEMBL8700474 | 0.90 | PTGS2 (0.77) | PTGS2ALOX5PTPRCRAB9AKDM4E | |
| SCHEMBL4789136 | 0.76 | PTGS2 (0.72) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL2692579 | 0.75 | CA12 (0.59) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL29629010 | 0.75 | PTGS2 (0.58) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL22162812 | 0.74 | CA12 (0.58) | PTGS2ALOX5PTPRCRAB9AKDM4E | |
| SCHEMBL10342540 | 0.74 | PTGS2 (0.53) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL30009937 | 0.74 | PTGS2 (0.66) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL404584 | 0.74 | PTGS2 (0.66) | PTGS2PTPRCRAB9AKDM4ENPC1 | |
| SCHEMBL7347238 | 0.73 | PTGS2 (0.51) | PTGS2ALOX5PTPRCRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2005-01-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014769-A1 | Use of endothelin receptor antogonists for the treatment of tumour diseases | EDNRA, EDNRB, ECE1 | PTGS2 247/4885ALOX5 890/4885PTPRC 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.