⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008015 | 0.77 | — | — | |
| SCHEMBL1569519 | 0.77 | — | — | |
| SCHEMBL3846079 | 0.74 | ALDH1A1 (0.39) | — | |
| SCHEMBL292231 | 0.73 | — | — | |
| SCHEMBL9401069 | 0.73 | — | — | |
| SCHEMBL15066916 | 0.72 | HPGD (0.37) | — | |
| SCHEMBL15066915 | 0.72 | HPGD (0.37) | — | |
| SCHEMBL7131085 | 0.71 | AHR (0.50) | — | |
| SCHEMBL10797650 | 0.70 | RELA (0.41) | — | |
| SCHEMBL15067238 | 0.70 | SRC (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | claimed |
| CN-107635970-A | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | 詹森药业有限公司 | 2018-01-26 | — | — | CN | claimed |
| US-6887877-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-05-03 | — | — | US | claimed |
| CN-106458810-B | Method for preparing 3-chloro-2-vinylphenol | 拜耳作物科学股份公司 | 2019-11-12 | — | — | CN | disclosed |
| CN-110035992-A | Process for preparing 3-substituted 2-vinylphenyl sulfonates | 拜耳作物科学股份公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-108440379-A | A kind of method of the alkene bisamination synthesis nitrogen-containing hetero cyclics of water phase | 安徽德信佳生物医药有限公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-108137549-A | FXIA inhibitor derived from novel substituted glycine | 百时美施贵宝公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-107750250-A | Indolone compounds and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-02 | — | — | CN | disclosed |
| CN-107635970-A | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | 詹森药业有限公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-104066737-B | As P2X7Heterocyclic amide derivatives of receptor antagonists | 埃科特莱茵药品有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-104066737-A | As P2X7Heterocyclic amide derivatives of receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2014-09-24 | — | — | CN | disclosed |