Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284406 | 0.81 | ADRA2A (0.53) | LMNAHIF1AADRA2AADRA2BADRA2C | |
| SCHEMBL2297898 | 0.72 | HIF1A (0.53) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL27711196 | 0.72 | HIF1A (0.53) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL2291082 | 0.72 | HIF1A (0.53) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL30526163 | 0.72 | SPHK1 (0.38) | ADRB2 | |
| SCHEMBL2293713 | 0.70 | HIF1A (0.69) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL2291633 | 0.70 | HIF1A (0.69) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL27711232 | 0.70 | HIF1A (0.69) | LMNAHIF1AGALR3ADRA2AADRA2B | |
| SCHEMBL7787318 | 0.70 | ADRB2 (0.32) | ADRA2AADRA2BADRA2CADRA1AKDM4E | |
| SCHEMBL7171627 | 0.70 | ADRA2C (0.50) | LMNAHIF1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878705-B2 | 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamide antiviral agents | PFIZER (US) | 2005-04-12 | — | — | US | disclosed |