Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 15/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3792498 | 0.80 | RBP4 (0.53) | RBP4SMN1; SMN2MAPK1USP2KMT2A | |
| SCHEMBL631780 | 0.79 | RBP4 (0.52) | RBP4SMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL766148 | 0.79 | RBP4 (0.56) | RBP4SMN1; SMN2MAPK1USP2 | |
| SCHEMBL631781 | 0.79 | RBP4 (0.50) | RBP4SMN1; SMN2MAPK1USP2KMT2A | |
| SCHEMBL766281 | 0.78 | RBP4 (0.54) | RBP4SMN1; SMN2MAPK1USP2ALDH1A1 | |
| SCHEMBL630593 | 0.76 | RBP4 (0.61) | RBP4SMN1; SMN2MAPK1USP2LMNA | |
| SCHEMBL766086 | 0.74 | L3MBTL1 (0.64) | RBP4 | |
| SCHEMBL766164 | 0.73 | GAA (0.70) | RBP4SMN1; SMN2MAPK1USP2TSHR | |
| SCHEMBL630839 | 0.73 | RBP4 (0.75) | RBP4ALDH1A1 | |
| SCHEMBL766323 | 0.72 | RBP4 (0.87) | RBP4SMN1; SMN2KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419413-A1 | DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010119992-A1 | DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-10-21 | — | — | WO | disclosed |