Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTPRF | P10586 | 1/20 | 0.39 |
| ▸ | GOT1 | P17174 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319180 | 0.84 | RAB9A (0.45) | ALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL6311429 | 0.84 | KDM4E (0.56) | CFDALDH1A1PTPN1RAB9ANPC1 | |
| SCHEMBL6319032 | 0.84 | GRIK1 (0.52) | CFDALDH1A1RAB9ANPC1KDM4E | |
| SCHEMBL6310351 | 0.83 | GRIK1 (0.51) | ALDH1A1RAB9ANPC1KDM4EMAPT | |
| SCHEMBL6319363 | 0.82 | KMT2A (0.43) | CFDALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL6310340 | 0.82 | LMNA (0.49) | CFDALDH1A1IKBKBPTPN1RAB9A | |
| SCHEMBL6320140 | 0.77 | GRIN1 (0.41) | ALDH1A1 | |
| SCHEMBL6316701 | 0.77 | ALDH1A1 (0.46) | ALDH1A1PTPN1RAB9ANPC1KDM4E | |
| SCHEMBL6312363 | 0.75 | SOAT1 (0.46) | ALDH1A1SOAT1 | |
| SCHEMBL6310632 | 0.75 | KMT2A (0.48) | ALDH1A1RAB9ANPSR1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2002-11-07 | — | — | US | claimed |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | US | claimed |
| EP-1062204-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046244-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2005-06-02 | — | — | US | disclosed |
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | JEPPESEN LONE (DK) | 2002-11-07 | — | — | US | disclosed |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2002-01-03 | — | — | US | disclosed |
| EP-1062204-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046244-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020165398-A1 | Modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPRO | CFD 4481/4885ALDH1A1 3669/4885IKBKB 1687/4885 |
| US-20020002199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | PTPRCAP, PTPRS, PTPRA | CFD 4493/4885ALDH1A1 3737/4885IKBKB 1694/4885 |
| US-20050119332-A1 | Substituted thiophene compounds as modulators of protein tyrosine phosphatases (PTPases) | PTPRCAP, PTPRS, PTPN1 | CFD 4786/4885ALDH1A1 2235/4885IKBKB 1544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.