Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.44 |
| ▸ | ITGAL | P20701 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196464 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6315906 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6318331 | 0.81 | ITGAL (0.62) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6199028 | 0.80 | ITGAL (0.56) | SMN1; SMN2NPC1RAB9AKDM4EITGB2 | |
| SCHEMBL6196886 | 0.80 | KDM4E (0.56) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6317023 | 0.80 | ITGAL (0.51) | NPC1RAB9AKDM4EPOLBITGB2 | |
| SCHEMBL6201623 | 0.80 | RAB9A (0.47) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6196634 | 0.79 | HTT (0.54) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6196589 | 0.79 | ITGB2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EGAA | |
| SCHEMBL6198997 | 0.77 | RAB9A (0.47) | SMN1; SMN2NPC1RAB9AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |