Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 8/20 | 0.62 |
| ▸ | ITGB2 | P05107 | 7/20 | 0.62 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196469 | 0.88 | ITGAL (0.78) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6567825 | 0.85 | ITGAL (0.54) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6315913 | 0.85 | ITGAL (0.54) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6496998 | 0.85 | KDM4E (0.59) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6496997 | 0.85 | KDM4E (0.59) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6318327 | 0.81 | SMN1; SMN2 (0.55) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6318322 | 0.80 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6199035 | 0.80 | ITGAL (0.82) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL7618530 | 0.80 | ITGAL (0.81) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 | |
| SCHEMBL6196889 | 0.80 | ITGAL (0.81) | ITGALITGB2ICAM1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |