Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312260 | 0.96 | OPRM1 (0.77) | OPRM1OPRD1 | |
| SCHEMBL6309378 | 0.91 | OPRM1 (1.00) | OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL6316222 | 0.90 | OPRM1 (0.98) | OPRM1OPRD1 | |
| SCHEMBL6316112 | 0.89 | OPRM1 (0.88) | OPRM1OPRD1 | |
| SCHEMBL6310463 | 0.88 | OPRM1 (0.74) | OPRM1OPRD1 | |
| SCHEMBL6398323 | 0.86 | OPRM1 (0.80) | OPRM1OPRD1 | |
| SCHEMBL6311259 | 0.86 | OPRM1 (0.71) | OPRM1OPRD1 | |
| SCHEMBL6309659 | 0.86 | OPRM1 (0.70) | OPRM1OPRD1 | |
| SCHEMBL6308778 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1 | |
| SCHEMBL6308694 | 0.85 | OPRM1 (0.94) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004163-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-01-06 | — | — | US | disclosed |
| US-20030181447-A1 | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | BOYD ROBERT E (US) | 2003-09-25 | — | — | US | disclosed |
| US-6552036-B2 | Delta-opioid or mu-opioid receptor modulators; useful analgesics, immunosuppressants, antiinflammatory agents, agents for the treatment of respiratory diseases. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-04-22 | — | — | US | disclosed |
| EP-1263758-A2 | 3-(DIARYLMETHYLENE)-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020115662-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | BOYD ROBERT E (US) | 2002-08-22 | — | — | US | disclosed |
| WO-2001066543-A2 | 3-(DIARYLMETHYLENE)-8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004163-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | OPRD1, OPRM1, OPRK1 | OPRM1 2/4885OPRD1 1/4885 |
| US-20020115662-A1 | 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OPRD1 3/4885 |
| US-20030181447-A1 | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives | OPRM1, OPRK1, OPRD1 | OPRM1 1/4885OPRD1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.