Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA2 | P00918 | 7/20 | 0.56 |
| ▸ | CA4 | P22748 | 7/20 | 0.56 |
| ▸ | CA7 | P43166 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317791 | 0.90 | ALDH1A1 (0.64) | ALDH1A1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL6316560 | 0.86 | SMN1; SMN2 (0.59) | ALDH1A1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL6324120 | 0.84 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2NAMPTNPC1RAB9A | |
| SCHEMBL6316411 | 0.81 | RAB9A (0.50) | ALDH1A1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL6318210 | 0.80 | DYRK1A (0.47) | ALDH1A1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL6315774 | 0.79 | RAB9A (0.56) | ALDH1A1KDM4EL3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL6316431 | 0.78 | CA1 (0.52) | ALDH1A1KDM4ECA1CA2CA4 | |
| SCHEMBL6323514 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KDM4EL3MBTL1CA1CA2 | |
| SCHEMBL6316517 | 0.78 | CA1 (0.52) | ALDH1A1CA1CA2CA4CA7 | |
| SCHEMBL6315186 | 0.78 | TDO2 (0.49) | ALDH1A1KDM4EL3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | claimed |
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059657-A1 | Aminoisoxazole derivatives active as kinase inhibitors | MAP3K9, MAP3K19, MAP4K2 | ALDH1A1 4444/4885KDM4E 1382/4885L3MBTL1 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.