Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134135 | 0.80 | ALDH1A1 (0.40) | ESR1ESR2CYP1A2CYP3A4NPC1 | |
| SCHEMBL6313489 | 0.80 | GRIN2D (0.42) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL2254563 | 0.79 | ESR1 (0.37) | ESR1ESR2ALOX5CYP1A2CYP2C19 | |
| SCHEMBL2724557 | 0.75 | ESR1 (0.58) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL1987912 | 0.75 | ESR1 (0.58) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL30703158 | 0.75 | ESR1 (0.58) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL1274645 | 0.74 | ALOX5 (0.44) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL3005121 | 0.73 | ESR1 (0.56) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL15189763 | 0.73 | ALOX5 (0.39) | ESR1ESR2ALOX5HSD17B1HSD17B2 | |
| SCHEMBL6537032 | 0.72 | ALDH1A1 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1217699-C | Preventives or remedies for arrhythmia | SHIONOGI & CO (JP) | 2005-09-07 | — | — | CN | disclosed |
| US-6924301-B1 | Composition for treating or preventing arrhythmia | SHIONOGI & CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| EP-0976748-B1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| CN-1411379-A | Preventives or remedies for arrhythmia | SHIONOGI & CO (JP) | 2003-04-16 | — | — | CN | disclosed |
| EP-1240906-A1 | PREVENTIVES OR REMEDIES FOR ARRHYTHMIA | SHIONOGI & CO., LTD. (JP) | 2002-09-18 | — | — | EP | disclosed |
| US-6147100-A | ANTIINFLAMMATORY AGENTS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0976748-A1 | PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |