Sugi Predict

Sugi Predict / Compounds / SCHEMBL6320570

SCHEMBL6320570

SCHEMBL6320570

[CH2]N(C)CC(O)c1ccc(O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.50
▸ TDP1 Q9NUW8 3/20 0.50
▸ HIF1A Q16665 2/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ CYP2C9 P11712 2/20 0.50
▸ HTR3A P46098 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ HTR1A P08908 1/20 0.50
▸ THPO P40225 1/20 0.50
▸ BLM P54132 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ NMUR2 Q9GZQ4 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ NFKB1 P19838 1/20 0.50
▸ AOC3 Q16853 6/20 0.48
▸ ALOX15 P16050 2/20 0.48
▸ APEX1 P27695 1/20 0.48
▸ ESR1 P03372 2/20 0.42
▸ SLC6A2 P23975 2/20 0.42
▸ OPRM1 P35372 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6320573 0.83 TAAR1 (0.54) TAAR1TDP1HIF1AKDM4ECYP2C9
SCHEMBL25101015 0.83 TAAR1 (0.54) TAAR1TDP1HIF1AKDM4ECYP2C9
SCHEMBL6284970 0.83 AOC3 (0.68) TAAR1TDP1KDM4EALDH1A1SMN1; SMN2
SCHEMBL6281298 0.82 AOC3 (0.68) KDM4ESMN1; SMN2AOC3SLC6A2SLC6A3
SCHEMBL6281260 0.82 AOC3 (0.68) KDM4ESMN1; SMN2AOC3SLC6A2LMNA
SCHEMBL6320185 0.81 AOC3 (0.46) TAAR1KDM4EALDH1A1SMN1; SMN2TSHR
SCHEMBL6318407 0.79 KDM4E (0.49) TAAR1KDM4EALDH1A1SMN1; SMN2TSHR
SCHEMBL6479386 0.79 AOC3 (0.70) ALDH1A1AOC3SLC6A2SLC6A3MAPT
SCHEMBL6281184 0.78 AOC3 (0.47) KDM4EAOC3SLC6A2SLC6A3LMNA
SCHEMBL6491739 0.78 HIF1A (0.56) TAAR1HIF1AKDM4EHTR1ABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6924283-B2 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents PFIZER (US) 2005-08-02 — — US claimed
US-6861438-B2 Antiviral agents PFIZER (US) 2005-03-01 — — US claimed
US-6852731-B2 Antiviral compounds PFIZER (US) 2005-02-08 — — US claimed
US-20040242884-A1 ANTIVIRAL COMPOUNDS PHARMACIA & UPJOHN COMPANY 2004-12-02 — — US claimed
US-20040138449-A1 Antiviral agents PHARMACIA & UPJOHN COMPANY 2004-07-15 — — US claimed
EP-1421089-A1 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS Pharmacia & Upjohn Company (US) 2004-05-26 — — EP claimed
EP-1421088-A1 4-THIOXO-4,7-DIHYDRO-THIENO 2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2004-05-26 — — EP claimed
US-6620810-B2 Treating a herpesvirus infection, atherosclerosis or restenosis PHARMACIA & UPJOHN COMPANY 2003-09-16 — — US claimed
US-20030109542-A1 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents PHARMACIA & UPJOHN COMPANY 2003-06-12 — — US claimed
US-20030100536-A1 4-Thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents PHARMACIA & UPJOHN COMPANY 2003-05-29 — — US claimed
WO-2003020730-A1 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-03-13 — — WO claimed
WO-2003020728-A1 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-03-13 — — WO claimed
WO-2003020729-A1 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANT IVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2003-03-13 — — WO claimed
JP-2002539130-A — — 2002-11-19 — — JP claimed
EP-1159279-B1 4-OXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS UPJOHN CO (US) 2002-10-16 — — EP claimed
CN-1347417-A 4-oxo-4,7-dihydro-thieno [2,3-b] pyridine-5-carboxamides as antiviral agent UPJOHN CO (US) 2002-05-01 — — CN claimed
US-20020006937-A1 4-OXO-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents PHARMACIA & UPJOHN COMPANY 2002-01-17 — — US claimed
EP-1159279-A2 4-OXO-4,7-DIHYDRO-THIENO[2,3-B]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2001-12-05 — — EP claimed
US-6239142-B1 HERPES VIRUS INFECTION PHARMACIA & UPJOHN COMPANY 2001-05-29 — — US claimed
WO-2000053610-A2 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2000-09-14 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030100536-A1 4-Thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents TPMT, TK1, TYMP TAAR1 692/4885TDP1 105/4885HIF1A 1546/4885
US-20040242884-A1 ANTIVIRAL COMPOUNDS ZC3HAV1, IRF3, IFNAR1 TAAR1 3943/4885TDP1 704/4885HIF1A 1264/4885
US-20040138449-A1 Antiviral agents IRF3, IFNAR1, EIF2AK2 TAAR1 3903/4885TDP1 396/4885HIF1A 1529/4885
US-20020006937-A1 4-OXO-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents IRF3, IL4, ZC3HAV1 TAAR1 3738/4885TDP1 942/4885HIF1A 1101/4885
US-20030109542-A1 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents IRF3, IRAK4, IFNAR1 TAAR1 1124/4885TDP1 273/4885HIF1A 826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.