Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.65 |
| ▸ | BRD4 | O60885 | 5/20 | 0.62 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.46 |
| ▸ | TAF1 | P21675 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | MDH2 | P40926 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320773 | 0.84 | TDP2 (0.55) | CRBNBRD4CREBBPABL1PIP4K2A | |
| SCHEMBL17680966 | 0.80 | CREBBP (0.68) | CRBNBRD4CREBBPTAF1PDK2 | |
| SCHEMBL23175435 | 0.79 | CRBN (1.00) | CRBNBRD4CREBBPPDK2HDAC8 | |
| SCHEMBL29899574 | 0.79 | CRBN (1.00) | CRBNBRD4CREBBPPDK2HDAC8 | |
| SCHEMBL17680816 | 0.77 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL6328529 | 0.76 | BRD4 (0.54) | BRD4CREBBPABL1PIP4K2APIP4K2B | |
| SCHEMBL6320660 | 0.75 | ABL1 (0.45) | BRD4CREBBPABL1PIP4K2APIP4K2B | |
| SCHEMBL5843496 | 0.75 | JAK2 (0.51) | BRD4CREBBPABL1PIP4K2APIP4K2B | |
| SCHEMBL155873 | 0.74 | GSK3B (0.50) | BRD4CREBBPABL1PIP4K2APIP4K2B | |
| SCHEMBL6319680 | 0.74 | PGR (0.58) | ABL1PIP4K2APIP4K2BTDP2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | CRBN 591/4885BRD4 180/4885CREBBP 174/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | CRBN 591/4885BRD4 180/4885CREBBP 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.