Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332748 | 0.96 | KMT2A (0.41) | SMN1; SMN2TSHRCYP1A2CYP2C9HPGD | |
| SCHEMBL6327197 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6326152 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6326416 | 0.86 | ALDH1A1 (0.50) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6328351 | 0.85 | GAA (0.51) | SMN1; SMN2TSHRHPGDLMNAALDH1A1 | |
| SCHEMBL5076377 | 0.85 | KMT2A (0.44) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6327152 | 0.85 | KMT2A (0.44) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6325758 | 0.85 | KMT2A (0.45) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6331317 | 0.85 | HDAC2 (0.48) | SMN1; SMN2TSHRLMNAALDH1A1MAPK1 | |
| SCHEMBL6334365 | 0.85 | HDAC1 (0.48) | SMN1; SMN2TSHRCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |