Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327432 | 0.95 | MAPT (0.54) | GAAMAPTLMNAUSP2TSHR | |
| SCHEMBL6326416 | 0.94 | ALDH1A1 (0.50) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6334365 | 0.93 | HDAC1 (0.48) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6331317 | 0.93 | HDAC2 (0.48) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6328273 | 0.92 | LMNA (0.48) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL5073454 | 0.92 | HDAC1 (0.51) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6328582 | 0.92 | HDAC1 (0.51) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6327919 | 0.90 | HDAC1 (0.42) | GAAHDAC2HDAC8HDAC1MAPT | |
| SCHEMBL6326400 | 0.89 | ALDH1A1 (0.52) | GAAMAPTLMNAUSP2TSHR | |
| SCHEMBL6327916 | 0.89 | NPSR1 (0.43) | GAAHDAC2HDAC8HDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |