Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | APEX1 | P27695 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14586773 | 0.88 | RXFP1 (0.67) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL2735819 | 0.87 | NPC1 (0.62) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL2735818 | 0.86 | NPC1 (0.71) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| 5-Fluoroindole-2-Carboxylic Acid SCHEMBL209759 | 0.85 | KDM4E (1.00) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL7533561 | 0.85 | NPC1 (0.74) | KDM4ELMNAHPGDHSD17B10NPC1 | |
| SCHEMBL8205048 | 0.85 | NHERF1 (0.64) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL8205586 | 0.85 | NHERF1 (0.68) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL2735815 | 0.85 | RXFP1 (0.70) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| SCHEMBL2735807 | 0.85 | NPC1 (0.62) | KDM4EALDH1A1LMNAPDPK1HPGD | |
| 5-Fluoroindole-2-Carboxylic Acid SCHEMBL213473 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1LMNAPDPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250835-A1 | Novel tumor-selective chemotherapeutic agents | WANG YUQIANG | 2005-11-10 | — | — | US | disclosed |
| WO-2005103040-A1 | CC-1065 ANALOGUES FOR USE AGAINST CANCERS | PANORAMA RESEARCH INC. (US) | 2005-11-03 | — | — | WO | disclosed |
| US-20050239864-A1 | Novel tumor-selective chemotherapeutic agents | WANG YUQIANG | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239864-A1 | Novel tumor-selective chemotherapeutic agents | ALB, ANXA5, FABP5 | KDM4E 4058/4885ALDH1A1 2665/4885LMNA 4329/4885 |
| US-20050250835-A1 | Novel tumor-selective chemotherapeutic agents | ALB, ANXA5, FABP5 | KDM4E 4058/4885ALDH1A1 2665/4885LMNA 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.