Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 3/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | PLD2 | O14939 | 1/20 | 0.56 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 2/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | F3 | P13726 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204182 | 0.97 | NHERF1 (0.60) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL8205586 | 0.94 | NHERF1 (0.68) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL10466165 | 0.90 | MAOA (0.71) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL7463929 | 0.90 | MEN1 (0.64) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL3498709 | 0.89 | EGFR (0.64) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL22718631 | 0.87 | MAOA (0.56) | NHERF1MAOAMAOBPLD2PLD1 | |
| SCHEMBL5680312 | 0.87 | NHERF1 (0.54) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL7533561 | 0.86 | NPC1 (0.74) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL22718578 | 0.86 | KCNK3 (0.55) | NHERF1MAOAMAOBEGFRPIK3CA | |
| SCHEMBL5897662 | 0.85 | NHERF1 (0.56) | NHERF1MAOAMAOBEGFRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359454-B1 | CC-1065 analogs having two CPI subunits | UPJOHN CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5541339-A | ANTITUMOR AGENTS | THE UPJOHN COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1990002746-A1 | NOVEL CC-1065 ANALOGS HAVING TWO CPI SUBUNITS | THE UPJOHN COMPANY (US) | 1990-03-22 | — | — | WO | disclosed |