Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | EGFR | P00533 | 8/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | DAO | P14920 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | NHERF1 | O14745 | 2/20 | 0.57 |
| ▸ | PYGL | P06737 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466165 | 0.90 | MAOA (0.71) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL5818325 | 0.87 | NPC1 (0.75) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL468970 | 0.86 | MAOB (0.74) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8205048 | 0.86 | NHERF1 (0.64) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL8205586 | 0.86 | NHERF1 (0.68) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL7208136 | 0.85 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL29475123 | 0.85 | NPC1 (1.00) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL5897662 | 0.85 | NHERF1 (0.56) | NPC1RAB9ALMNASMN1; SMN2EGFR | |
| SCHEMBL6323639 | 0.85 | KDM4E (0.73) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL7463929 | 0.84 | MEN1 (0.64) | NPC1RAB9ALMNASMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2830614-B1 | CYCLIC PRODRUGS OF DUOCARMYCIN ANALOGS | SCRIPPS RESEARCH INST (US) | 2017-04-26 | — | — | EP | disclosed |
| US-9586974-B2 | Cyclic N-acyl O-amino phenol CBI derivative | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160016972-A1 | Cyclic N-Acyl O-Amino Phenol CBI Derivative | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-01-21 | — | — | US | disclosed |
| US-9139596-B2 | Cyclic prodrugs of duocarmycin analogs | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-09-22 | — | — | US | disclosed |
| US-20150057270-A1 | CYCLIC PRODRUGS OF DUOCARMYCIN ANALOGS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-26 | — | — | US | disclosed |
| WO-2014160586-A1 | CYCLIC N-ACYL O-AMINO PHENOL CBI DERIVATIVE | THE SCRIPPS RESEARCH LINSTITUTE (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2013148631-A1 | CYCLIC PRODRUGS OF DUOCARMYCIN ANALOGS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-10-03 | — | — | WO | disclosed |
| US-7214685-B2 | Prodrugs for a selective cancer therapy | Tietze, Lutz F. (DE) | 2007-05-08 | — | — | US | disclosed |
| US-7214685-B2 | Prodrugs for a selective cancer therapy | Tietze, Lutz F. (DE) | 2007-05-08 | — | — | US | disclosed |
| EP-0656360-B1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN SEIYAKU KK (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5629430-A | ANTICARCINOGENIC AGENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0656360-A1 | TRIFLUOROMETHYLPYRROLOINDOLE CARBOXYLIC ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| US-4978757-A | BACTERICIDES, ANTITUMOR AGENTS, UV RAD ABSORBERS | THE UPJOHN COMPANY (US) | 1990-12-18 | — | — | US | disclosed |
| US-4912227-A | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds | THE UPJOHN COMPANY (US) | 1990-03-27 | — | — | US | disclosed |
| EP-0154445-B1 | ANALOGUES OF ANTIBIOTIC CC-1065 | THE UPJOHN COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0154445-A1 | Analogues of antibiotic cc-1065 | THE UPJOHN COMPANY (US) | 1985-09-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016972-A1 | Cyclic N-Acyl O-Amino Phenol CBI Derivative | CCNI, DBI, SUB1 | NPC1 2376/4885RAB9A 3534/4885LMNA 190/4885 |
| US-20150057270-A1 | CYCLIC PRODRUGS OF DUOCARMYCIN ANALOGS | DCK, DCTD, DUT | NPC1 2804/4885RAB9A 3127/4885LMNA 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.