Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28405624 | 0.84 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL29527038 | 0.82 | — | — | |
| SCHEMBL95292 | 0.82 | — | — | |
| SCHEMBL3905460 | 0.81 | LMNA (0.40) | LMNAKMT2AMEN1THRBBLM | |
| Fluoride SCHEMBL28846655 | 0.80 | KMT2A (0.60) | LMNAKMT2AMEN1THRBBLM | |
| Dimethoxymethane SCHEMBL28351416 | 0.79 | LMNA (0.44) | LMNAKMT2AMEN1THRBBLM | |
| Ethylene SCHEMBL9871986 | 0.78 | LMNA (0.38) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL10859526 | 0.78 | NFE2L2 (0.44) | LMNAKMT2AMEN1THRBBLM | |
| Salicyladehyde SCHEMBL11795089 | 0.78 | TRIM24 (0.67) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL2220992 | 0.78 | NFE2L2 (0.45) | LMNAKMT2AMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110092734-B | Tandem synthesis method of 2- (phenylmethylene) malononitrile or derivatives thereof | 华侨大学 | 2021-12-31 | — | — | CN | disclosed |
| CN-110092734-A | A kind of 2-(phenylmethylene) malononitrile or derivatives thereof series connection synthetic method | 华侨大学 | 2019-08-06 | — | — | CN | disclosed |
| CN-101426796-A | Meridamycin analogs for the treatment of neurodegenerative disorders | WYETH CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| EP-0900210-B1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 2005-02-09 | — | — | EP | disclosed |
| US-6300519-B1 | REACTING HYDRAZINE DERIVATIVE WITH EPOXIDE COMPOUND | NOVARTIS FINANCE CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6166004-A | Combinations of HIV protease inhibitors with reverse transcriptase inhibitors | NOVARTIS FINANCE CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| EP-0900210-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | Novartis AG (CH) | 1999-03-10 | — | — | EP | disclosed |
| US-5849911-A | Antivirally active heterocyclic azahexane derivatives | NOVARTIS FINANCE CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| WO-1997040029-A1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 1997-10-30 | — | — | WO | disclosed |
| US-5070103-A | ANTILIPEMIC AGENTS, ARTERIOSCLEROSIS | TANABE SEIYAKU CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |