Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.54 |
| ▸ | GOT1 | P17174 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.40 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326839 | 0.85 | ASH1L (0.51) | ABL1BCRPIK3CDGOT1PIK3CB | |
| SCHEMBL7090984 | 0.80 | PIK3CD (0.63) | PIK3CDGOT1PIK3CBPIK3CGASH1L | |
| SCHEMBL6322049 | 0.80 | PIK3CD (0.58) | ABL1BCRPIK3CDGOT1PIK3CB | |
| SCHEMBL31413326 | 0.80 | PIK3CD (0.58) | ABL1BCRPIK3CDGOT1PIK3CB | |
| SCHEMBL28109256 | 0.79 | BRD4 (0.49) | ABL1BCRPIK3CDTTBK1TTBK2 | |
| SCHEMBL7088143 | 0.78 | PIK3CD (0.57) | PIK3CDGOT1PIK3CBPIK3CGASH1L | |
| SCHEMBL10945814 | 0.78 | PIK3CD (0.75) | PIK3CDPIK3CBPIK3CGASH1LCSNK2B | |
| SCHEMBL18002679 | 0.78 | ABL1 (0.45) | ABL1BCRPIK3CDGOT1PIK3CB | |
| SCHEMBL6322152 | 0.77 | PIK3CD (0.64) | ABL1PIK3CDPIK3CBPIK3CGASH1L | |
| SCHEMBL27725234 | 0.75 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGASH1LCSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| US-20040157909-A1 | 4-Aryl substituted indolinones | SUGEN, INC. | 2004-08-12 | — | — | US | disclosed |
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | disclosed |
| US-20030203959-A1 | Novel modulators of potassium channels | 4SC AG (DE) | 2003-10-30 | — | — | US | disclosed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | ABL1 20/4885BCR 1129/4885PIK3CD 365/4885 |
| US-20030203959-A1 | Novel modulators of potassium channels | HCN3, KCNN3, KCNN1 | ABL1 3070/4885BCR 2549/4885PIK3CD 3331/4885 |
| US-20040157909-A1 | 4-Aryl substituted indolinones | CDK5, CAMK4, TNK2 | ABL1 20/4885BCR 1129/4885PIK3CD 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.