Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20331 | 0.80 | TSHR (0.44) | HPGDTSHRRAB9AKDM4EHTR1D | |
| SCHEMBL1843380 | 0.66 | TSHR (0.46) | HPGDTSHRRAB9AKDM4EHTR1D | |
| SCHEMBL24423316 | 0.65 | ESR1 (0.48) | HPGDTSHRKIF11ALDH1A1ALOX15 | |
| SCHEMBL7287002 | 0.65 | TSHR (0.44) | HPGDTSHRRAB9AKDM4EHTR1D | |
| SCHEMBL7286991 | 0.65 | TSHR (0.44) | HPGDTSHRRAB9AKDM4EHTR1D | |
| SCHEMBL11157398 | 0.65 | PDE2A (0.42) | TSHRKIF11ALDH1A1 | |
| SCHEMBL12169311 | 0.64 | TSHR (0.45) | HPGDTSHRKDM4EKIF11ALDH1A1 | |
| SCHEMBL29403104 | 0.64 | ALDH1A1 (0.46) | HPGDTSHRRAB9ACYP1A2CYP2C19 | |
| SCHEMBL179803 | 0.64 | ALDH1A1 (0.46) | HPGDTSHRRAB9ACYP1A2CYP2C19 | |
| SCHEMBL2009857 | 0.63 | TSHR (0.52) | HPGDTSHRRAB9AKDM4EHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967247-B2 | Deprotection of phosphorus in oligonucleotide synthesis | ISIS PHARMACEUTICALS, INC. (US) | 2005-11-22 | — | — | US | disclosed |
| US-20040024194-A1 | Deprotection of phosphorus in oligonucleotide synthesis | ISIS PHARMACEUTICALS, INC. | 2004-02-05 | — | — | US | disclosed |
| WO-2004009612-A1 | DEPROTECTION OF PHOSPHORUS IN OLIGONUCLEOTIDE SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024194-A1 | Deprotection of phosphorus in oligonucleotide synthesis | OR51E2, PNKP, RNGTT | HPGD 4490/4885TSHR 1151/4885RAB9A 4845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.