Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 17/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 17/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 16/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 16/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 14/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20722399 | 0.78 | CHRNB2 (0.35) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL6323750 | 0.76 | NR1H2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18668699 | 0.74 | SMN1; SMN2 (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL29963571 | 0.74 | SMN1; SMN2 (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL23523345 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL29090938 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL20898688 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL29090937 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL23523344 | 0.71 | SMN1; SMN2 (0.32) | — | |
| SCHEMBL25391666 | 0.70 | CHRNB2 (0.64) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |
| EP-1192154-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |