Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 6/20 | 0.65 |
| ▸ | METAP2 | P50579 | 4/20 | 0.53 |
| ▸ | METAP1 | P53582 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | HTRA1 | Q92743 | 5/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329760 | 0.79 | PIN1 (1.00) | PIN1CTSL | |
| SCHEMBL6326344 | 0.79 | PIN1 (1.00) | PIN1CTSL | |
| SCHEMBL6258485 | 0.78 | PIN1 (0.51) | PIN1METAP2METAP1CTSLCTSS | |
| SCHEMBL17843413 | 0.78 | GRN (0.62) | PIN1METAP2METAP1CTSLCTSS | |
| SCHEMBL17843401 | 0.78 | GRN (0.62) | PIN1METAP2METAP1CTSLCTSS | |
| SCHEMBL30334963 | 0.78 | GRN (0.62) | PIN1METAP2METAP1CTSLCTSS | |
| SCHEMBL28979552 | 0.77 | CTSS (0.66) | METAP2METAP1CTSLCTSSCTSK | |
| SCHEMBL6268440 | 0.77 | PIN1 (0.79) | PIN1METAP2 | |
| SCHEMBL29397792 | 0.77 | CTSS (0.66) | METAP2METAP1CTSLCTSSCTSK | |
| SCHEMBL17859965 | 0.77 | CTSS (0.66) | METAP2METAP1CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250742-A1 | Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1) | PFIZER INC. | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250742-A1 | Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1) | PIN1, PSTPIP2, NIM1K | PIN1 1/4885METAP2 1571/4885METAP1 1108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.