Sugi Predict

Sugi Predict / Compounds / SCHEMBL6325375

SCHEMBL6325375

SCHEMBL6325375

Cc1[nH]c2ccc(C(=O)O)cc2c1Cc1ccc(-c2ccco2)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTPN5 P54829 1/20 0.48
▸ KDM4E B2RXH2 5/20 0.43
▸ ALDH1A1 P00352 3/20 0.43
▸ THRB P10828 2/20 0.43
▸ HPGD P15428 1/20 0.43
▸ PSMD14 O00487 1/20 0.43
▸ RECQL P46063 1/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ KEAP1 Q14145 1/20 0.43
▸ APEX1 P27695 1/20 0.43
▸ GPR17 Q13304 1/20 0.42
▸ PPARG P37231 1/20 0.41
▸ POLB P06746 2/20 0.39
▸ MAPT P10636 3/20 0.39
▸ GABRA1 P14867 2/20 0.38
▸ GABRG2 P18507 2/20 0.38
▸ GABRB3 P28472 2/20 0.38
▸ GABRA5 P31644 2/20 0.38
▸ GABRA3 P34903 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6319227 0.90 MEN1 (0.44) PTPN5KDM4EALDH1A1HPGDMAPT
SCHEMBL5881662 0.86 PTPN5 (0.53) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL6320276 0.83 PTGS2 (0.41) KDM4EALDH1A1TDP1POLBMAPT
SCHEMBL6317321 0.82 PPARG (0.41) KDM4EALDH1A1HPGDPPARGPOLB
SCHEMBL5881620 0.81 PTPN5 (0.57) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL6322418 0.81 PTPN5 (0.48) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL5881790 0.80 PTPN5 (0.58) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL5881650 0.79 PTPN5 (0.55) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL6326442 0.79 PTPN5 (0.55) PTPN5KDM4EALDH1A1THRBHPGD
SCHEMBL6319379 0.77 PTPN5 (0.50) PTPN5KDM4EALDH1A1THRBHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050171185-A1 Indole derivatives FUJISAWA PHARMACEUTICAL CO., LTD., A JAPANESE CORPORATION 2005-08-04 — — US disclosed
EP-1501830-A1 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES Actelion Pharmaceuticals Ltd. (CH) 2005-02-02 — — EP disclosed
CN-1150167-C Indole derivatives ����ҩƷ��ҵ��ʽ���� 2004-05-19 — — CN disclosed
WO-2003093267-A1 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES ACTELION PHARMACEUTICALS LTD (CH) 2003-11-13 — — WO disclosed
CN-1303371-A Indole derivatives FUJISAWA PHARMACEUTICAL CO (JP) 2001-07-11 — — CN disclosed
EP-1070705-A1 INDOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-01-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050171185-A1 Indole derivatives PDE5A, IGFBP5, HTR5A PTPN5 108/4885KDM4E 942/4885ALDH1A1 293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.