Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.69 |
| ▸ | CCND1 | P24385 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | CTSV | O60911 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332607 | 0.90 | PARP1 (0.62) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL31312450 | 0.90 | PARP1 (0.62) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL29360002 | 0.89 | GAA (0.67) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL354414 | 0.89 | GAA (0.67) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL29423967 | 0.89 | GAA (0.67) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL30235013 | 0.88 | CDK4 (0.79) | CDK4CCND1ALDH1A1KDM4EPARP1 | |
| SCHEMBL1181826 | 0.88 | CDK4 (0.79) | CDK4CCND1ALDH1A1KDM4EPARP1 | |
| SCHEMBL5335867 | 0.87 | PARP1 (0.59) | CDK4CCND1GAAALDH1A1KDM4E | |
| SCHEMBL31473178 | 0.87 | PARP1 (0.59) | CDK4CCND1GAAALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6432050 | 0.86 | CDK4 (0.76) | CDK4CCND1ALDH1A1KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | CDK4 506/4885CCND1 191/4885GAA 2065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.