Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332757 | 0.81 | SMN1; SMN2 (0.54) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL6340069 | 0.79 | BRD4 (0.75) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL6323777 | 0.74 | KDM4E (0.56) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL5160111 | 0.74 | MAPT (0.75) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL6326092 | 0.73 | MAPT (0.61) | LMNAKMT2AKDM4EPOLBPARP1 | |
| SCHEMBL13858810 | 0.72 | KDM4E (0.66) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL17444768 | 0.71 | AR (0.64) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL4713932 | 0.71 | SMN1; SMN2 (0.61) | BRD4TDP1LMNAKMT2AKDM4E | |
| SCHEMBL9584535 | 0.71 | CYP1A2 (0.78) | LMNAKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL1789242 | 0.69 | LMNA (1.00) | LMNAKMT2AKDM4EPARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |