Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927653 | 0.87 | HSD11B1 (0.55) | HSD11B1JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL6335547 | 0.85 | HSD11B1 (0.51) | HSD11B1GRIN2BACHES1PR1S1PR5 | |
| SCHEMBL31288362 | 0.84 | JAK2 (0.43) | JAK2JAK1KMT2AL3MBTL1GRIN2B | |
| SCHEMBL31282630 | 0.84 | JAK2 (0.43) | JAK2JAK1KMT2AL3MBTL1GRIN2B | |
| SCHEMBL6329847 | 0.84 | JAK2 (0.44) | JAK2JAK1KMT2AL3MBTL1GRIN2B | |
| SCHEMBL584913 | 0.81 | JAK2 (0.48) | HSD11B1JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL3237901 | 0.80 | HSD11B1 (0.44) | HSD11B1JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL16053284 | 0.78 | KCNK3 (0.55) | JAK2JAK1GRIN2BS1PR1S1PR5 | |
| SCHEMBL649847 | 0.78 | KCNK3 (0.55) | JAK2JAK1GRIN2BS1PR1S1PR5 | |
| SCHEMBL584450 | 0.78 | KCNK3 (0.55) | JAK2JAK1GRIN2BS1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004113-A1 | New bispidine compounds useful in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2005-01-06 | — | — | US | disclosed |
| EP-1192156-B1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004113-A1 | New bispidine compounds useful in the treatment of cardiac arrhythmias | DRD2, ADRA1D, KCND2 | HSD11B1 2935/4885JAK2 3221/4885JAK1 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.