Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.50 |
| ▸ | ESRRA | P11474 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL76794 | 0.86 | NOTUM (0.64) | NOTUMCYP19A1KEAP1LMNA | |
| SCHEMBL6827358 | 0.81 | NOTUM (0.55) | NOTUMCYP19A1KCNJ1KEAP1MAPK9 | |
| SCHEMBL462839 | 0.80 | NOTUM (0.56) | NOTUMCYP19A1KCNJ1CA12CA1 | |
| SCHEMBL6326785 | 0.79 | L3MBTL1 (0.56) | NOTUMCYP19A1CA12CA1CA2 | |
| SCHEMBL18865501 | 0.78 | KCNJ1 (0.62) | NOTUMCYP19A1KCNJ1KEAP1KMT2A | |
| SCHEMBL460993 | 0.78 | NOTUM (0.59) | NOTUMCYP19A1KCNJ1KEAP1MAPK9 | |
| SCHEMBL10447781 | 0.76 | NOTUM (0.78) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL22391983 | 0.74 | HTT (0.55) | NOTUMCYP19A1CA12CA1CA2 | |
| SCHEMBL15520031 | 0.74 | NOTUM (0.54) | NOTUMCYP19A1MAPK9MAPK10HPGD | |
| SCHEMBL31638362 | 0.74 | NOTUM (0.54) | NOTUMCYP19A1KCNJ1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | BRISTOL-MYERS SQUIBB CO. | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124664-A1 | Urea thiadiazole inhibitors of plasminogen activator inhibior-1 | SERPINE1, SERPINC1, SERPINB1 | NOTUM 4337/4885ESRRA 2404/4885CYP19A1 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.