Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25804575 | 0.82 | HPGD (0.58) | HPGDKMT2AMEN1RXFP1ALDH1A1 | |
| Formic Acid SCHEMBL6325576 | 0.82 | CYP1A2 (0.64) | ALDH1A1MAPTACHEPOLBSMN1; SMN2 | |
| Formic Acid SCHEMBL6327968 | 0.79 | DRD2 (0.61) | HPGDKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL14221228 | 0.78 | HDAC1 (0.70) | HPGDKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2555132 | 0.77 | ALDH1A1 (0.59) | ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| Formic Acid SCHEMBL6325030 | 0.77 | TSHR (0.67) | KMT2AMEN1ALDH1A1NPSR1BCHE | |
| SCHEMBL20999332 | 0.76 | HPGD (0.64) | HPGDKMT2AMEN1RXFP1ALDH1A1 | |
| SCHEMBL20999293 | 0.76 | HPGD (0.64) | HPGDKMT2AMEN1RXFP1ALDH1A1 | |
| SCHEMBL4734772 | 0.76 | MEN1 (0.83) | HPGDKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL25811671 | 0.76 | ALDH1A1 (0.63) | HPGDKMT2AMEN1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093267-A1 | 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-11-13 | — | — | WO | disclosed |