Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.52 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.49 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28668110 | 0.92 | ALDH1A1 (0.60) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL19555741 | 0.90 | ALDH1A1 (0.59) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL25796695 | 0.87 | ALDH1A1 (0.59) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28654035 | 0.87 | ALDH1A1 (0.77) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28655075 | 0.85 | ALDH1A1 (0.59) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28668119 | 0.85 | ALDH1A1 (0.59) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28649855 | 0.82 | GBA1 (0.57) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28650418 | 0.82 | GBA1 (0.56) | ALDH1A1GRIN1GRIN2BMEN1PPARG | |
| SCHEMBL28649848 | 0.81 | OGG1 (0.58) | ALDH1A1GRIN1GRIN2BKDM4ELMNA | |
| SCHEMBL30271523 | 0.81 | ALDH1A1 (0.55) | ALDH1A1GRIN1GRIN2BMEN1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |