Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21916800 | 0.76 | RAB9A (0.56) | ALDH1A1RAB9ALMNACHEK1AKT2 | |
| SCHEMBL28256160 | 0.76 | ALDH1A1 (0.50) | ALDH1A1RAB9APTGS2LMNAPDGFRA | |
| SCHEMBL4481508 | 0.75 | ALDH1A1 (0.73) | ALDH1A1RAB9ALMNAPDGFRAMAPK8 | |
| SCHEMBL6328965 | 0.75 | KDR (0.58) | LMNACHEK1PDGFRACLK4ALOX15 | |
| SCHEMBL28443142 | 0.74 | ALDH1A1 (0.55) | ALDH1A1RAB9ALMNACHEK1AKT2 | |
| SCHEMBL28645979 | 0.74 | ALDH1A1 (0.71) | ALDH1A1RAB9ALMNACHEK1GAA | |
| SCHEMBL6326979 | 0.71 | ALK (0.50) | LMNAPDGFRACLK4ALOX15TDP1 | |
| SCHEMBL28256157 | 0.71 | ALDH1A1 (0.41) | ALDH1A1RAB9APTGS2LMNACHEK1 | |
| SCHEMBL7298629 | 0.70 | LMNA (0.51) | ALDH1A1RAB9APTGS2LMNACHEK1 | |
| SCHEMBL4460442 | 0.69 | ALDH1A1 (0.75) | ALDH1A1RAB9ALMNAGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032871-A1 | Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors | MAP3K20, CDK20, STK10 | ALDH1A1 1803/4885RAB9A 949/4885PTGS2 1016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.