SCHEMBL6329476

SCHEMBL6329476

[c]1cccc(-c2cccnc2)c1CNC1CCC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
KDM4E B2RXH2 1/20 0.49
PKM P14618 1/20 0.49
KCNH2 Q12809 3/20 0.39
OPRL1 P41146 2/20 0.39
GBA1 P04062 3/20 0.38
ADRA2C P18825 1/20 0.38
PIM1 P11309 1/20 0.38
HPGDS O60760 1/20 0.36
USP2 O75604 1/20 0.36
CYP1A2 P05177 1/20 0.36
ALOX15 P16050 1/20 0.36
HIF1A Q16665 1/20 0.36
HSD17B10 Q99714 1/20 0.36
WNT1 P04628 1/20 0.36
DYRK1A Q13627 1/20 0.36
CYP2D6 P10635 1/20 0.35
GRIN2B Q13224 1/20 0.35
IDO1 P14902 1/20 0.35
KCNA5 P22460 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6322030 0.97 ALDH1A1 (0.52) ALDH1A1KDM4EPKMKCNH2OPRL1
SCHEMBL6324148 0.87 KDM4E (0.39) ALDH1A1KDM4EPKMKCNH2USP2
SCHEMBL6331308 0.85 KDM4E (0.42) ALDH1A1KDM4EPKMKCNH2USP2
SCHEMBL6636865 0.84 MEN1 (0.43) ALDH1A1KCNH2GRIN2B
SCHEMBL6640137 0.81 KMT2A (0.43) ALDH1A1KCNH2USP2GRIN2B
SCHEMBL6325686 0.81 PIM1 (0.41) GBA1ADRA2CPIM1HPGDSCYP2D6
SCHEMBL6322714 0.79 KDM4E (0.38) ALDH1A1KDM4EPKMKCNH2OPRL1
SCHEMBL21408620 0.78 MEN1 (0.49) ALDH1A1GRIN2B
SCHEMBL6324190 0.76 KDM4E (0.40) ALDH1A1KDM4EPKMKCNH2OPRL1
SCHEMBL6328543 0.76 GPR39 (0.39) ALDH1A1KDM4EPKMKCNH2OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951872-B2 Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-10-04 US disclosed
US-6858616-B2 Nitrogen containing heterobicycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-02-22 US disclosed
EP-1140871-A4 THROMBIN OR FACTOR XA INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-05-06 EP disclosed
US-6500855-B1 NITROGEN CONTAINING AROMATIC HETEROCYCLES WITH ORTHO-SUBSTITUTED P1 GROUPS; ANTICOAGULANTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-31 US disclosed
US-6413980-B1 INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASE ENZYMES; ANTICOAGULANTS; THROMBOEMBOLIC DISORDERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-07-02 US disclosed
US-6369227-B1 BLOOD COAGULATION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-09 US disclosed
EP-1140941-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
EP-1140871-A1 THROMBIN OR FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
WO-2000039108-A1 THROMBIN OR FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed
WO-2000039131-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed