SCHEMBL6324148

SCHEMBL6324148

[c]1cccc(-c2cncnc2)c1CNC1CCC1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 1/20 0.39
PKM P14618 1/20 0.39
KCNH2 Q12809 2/20 0.37
CYP2D6 P10635 1/20 0.37
GRIN2B Q13224 1/20 0.37
GLA P06280 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HRH3 Q9Y5N1 1/20 0.35
CD274 Q9NZQ7 2/20 0.34
ROCK2 O75116 4/20 0.33
ROCK1 Q13464 4/20 0.33
CDC42BPB Q9Y5S2 4/20 0.33
CDC42BPA Q5VT25 2/20 0.33
MAP4K4 O95819 1/20 0.33
USP2 O75604 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6331308 0.97 KDM4E (0.42) KDM4EALDH1A1PKMKCNH2CYP2D6
SCHEMBL6329476 0.87 ALDH1A1 (0.49) KDM4EALDH1A1PKMKCNH2CYP2D6
SCHEMBL6322030 0.85 ALDH1A1 (0.52) KDM4EALDH1A1PKMKCNH2CYP2D6
SCHEMBL6636865 0.83 MEN1 (0.43) ALDH1A1KCNH2GRIN2BGLAHTT
SCHEMBL6640137 0.81 KMT2A (0.43) ALDH1A1KCNH2GRIN2BGLAHTT
SCHEMBL6320544 0.79 CYP2D6 (0.35) KCNH2CYP2D6GRIN2BROCK2ROCK1
SCHEMBL6322714 0.78 KDM4E (0.38) KDM4EALDH1A1PKMKCNH2GLA
SCHEMBL21408620 0.77 MEN1 (0.49) ALDH1A1GRIN2BNPSR1HRH3CD274
SCHEMBL6324190 0.76 KDM4E (0.40) KDM4EALDH1A1PKMKCNH2GLA
SCHEMBL6328543 0.75 GPR39 (0.39) KDM4EALDH1A1PKMKCNH2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6951872-B2 Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-10-04 US disclosed
US-6858616-B2 Nitrogen containing heterobicycles as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2005-02-22 US disclosed
EP-1140871-A4 THROMBIN OR FACTOR XA INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-05-06 EP disclosed
US-6500855-B1 NITROGEN CONTAINING AROMATIC HETEROCYCLES WITH ORTHO-SUBSTITUTED P1 GROUPS; ANTICOAGULANTS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-31 US disclosed
US-6413980-B1 INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASE ENZYMES; ANTICOAGULANTS; THROMBOEMBOLIC DISORDERS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-07-02 US disclosed
US-6369227-B1 BLOOD COAGULATION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-04-09 US disclosed
EP-1140941-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
EP-1140871-A1 THROMBIN OR FACTOR XA INHIBITORS Du Pont Pharmaceuticals Company (US) 2001-10-10 EP disclosed
WO-2000039131-A1 NITROGEN CONTAINING HETEROBICYCLES AS FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed
WO-2000039108-A1 THROMBIN OR FACTOR XA INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 2000-07-06 WO disclosed