Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 8/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515233 | 0.79 | HDAC3 (0.47) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL559917 | 0.79 | HDAC2 (1.00) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL1325253 | 0.79 | HDAC2 (1.00) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL94335 | 0.77 | TGM2 (0.67) | EGFRMMP1MMP2MMP9MAOB | |
| SCHEMBL1515664 | 0.76 | HTT (0.49) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| Styrene SCHEMBL4224293 | 0.74 | HDAC2 (0.61) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| Styrene SCHEMBL4213157 | 0.74 | HDAC2 (0.61) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL3638056 | 0.74 | SLC6A19 (0.49) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL4962704 | 0.74 | MME (0.51) | HDAC2HDAC1HDAC3HDAC8HDAC6 | |
| SCHEMBL7520233 | 0.74 | ALDH1A1 (0.50) | HDAC2HDAC1HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153965-A1 | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153965-A1 | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade | TFPI, F2, PLAT | HDAC2 1130/4885HDAC1 1050/4885HDAC3 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.