Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6333323 | 1.00 | DRD2 (0.42) | DRD2HTR1AACHESIGMAR1ALDH1A1 | |
| SCHEMBL6333322 | 1.00 | DRD2 (0.42) | DRD2HTR1AACHESIGMAR1ALDH1A1 | |
| SCHEMBL6332479 | 0.89 | ACHE (0.41) | DRD2HTR1AACHESIGMAR1DRD4 | |
| SCHEMBL6332488 | 0.89 | ACHE (0.41) | DRD2HTR1AACHESIGMAR1DRD4 | |
| SCHEMBL6332483 | 0.89 | ACHE (0.41) | DRD2HTR1AACHESIGMAR1DRD4 | |
| SCHEMBL6335107 | 0.88 | HTR1A (0.47) | DRD2HTR1AACHESIGMAR1BCHE | |
| SCHEMBL6333556 | 0.82 | ACHE (0.42) | DRD2HTR1AACHESIGMAR1KDM4E | |
| SCHEMBL6333560 | 0.82 | ACHE (0.42) | DRD2HTR1AACHESIGMAR1KDM4E | |
| SCHEMBL6333555 | 0.82 | ACHE (0.42) | DRD2HTR1AACHESIGMAR1KDM4E | |
| SCHEMBL6333478 | 0.81 | ACHE (0.40) | DRD2HTR1AACHESIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1204659-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009122-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |