Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1476988 | 0.98 | KDM4E (0.57) | KDM4EPOLBRECQLMAPTHTT | |
| Iodide SCHEMBL29226832 | 0.96 | KDM4E (0.55) | KDM4EPOLBRECQLMAPTHTT | |
| Bromide SCHEMBL2482814 | 0.96 | KDM4E (0.59) | KDM4EPOLBRECQLMAPTHTT | |
| Iodide SCHEMBL30920085 | 0.96 | KDM4E (0.56) | KDM4EPOLBRECQLMAPTHTT | |
| Iodide SCHEMBL1343656 | 0.96 | KDM4E (0.56) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL6332993 | 0.91 | KDM4E (0.51) | KDM4EPOLBRECQLMAPTHTT | |
| Butyric Acid SCHEMBL1362446 | 0.84 | KDM4E (0.72) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL9934703 | 0.84 | KDM4E (0.58) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL12201164 | 0.83 | KDM4E (0.62) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL6333000 | 0.83 | KDM4E (0.48) | KDM4EPOLBRECQLMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143923-B1 | AGENT AND METHOD FOR COLOURING FIBRES | WELLA AG (DE) | 2004-05-06 | — | — | EP | claimed |
| US-6485529-B1 | Agent and method for coloring fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2002-11-26 | — | — | US | claimed |
| EP-1143923-A1 | AGENT AND METHOD FOR COLOURING FIBRES | Wella Aktiengesellschaft (DE) | 2001-10-17 | — | — | EP | claimed |
| WO-2001028507-A1 | AGENT AND METHOD FOR COLOURING FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2001-04-26 | — | — | WO | claimed |
| US-6977001-B2 | Dye compositions containing quinolinium salts | WELLA AG (DE) | 2005-12-20 | — | — | US | disclosed |
| EP-1143923-B1 | AGENT AND METHOD FOR COLOURING FIBRES | WELLA AG (DE) | 2004-05-06 | — | — | EP | disclosed |
| US-20030177592-A1 | Dye compositions containing quinolinium salts | HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) | 2003-09-25 | — | — | US | disclosed |
| EP-1346719-A1 | Dyeing compositions containing quinolinium salts | Wella Aktiengesellschaft (DE) | 2003-09-24 | — | — | EP | disclosed |
| US-6485529-B1 | Agent and method for coloring fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2002-11-26 | — | — | US | disclosed |
| EP-1143923-A1 | AGENT AND METHOD FOR COLOURING FIBRES | Wella Aktiengesellschaft (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001028507-A1 | AGENT AND METHOD FOR COLOURING FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2001-04-26 | — | — | WO | disclosed |