Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851295 | 0.89 | MAPK14 (0.40) | CPT1ASCN9AACHESCN10AALDH1A1 | |
| SCHEMBL4861342 | 0.76 | MAPK14 (0.37) | CPT1AFKBP1AKDM4ELMNA | |
| SCHEMBL27537569 | 0.72 | MAPK14 (0.41) | CPT1ANPC1ALDH1A1FKBP1AKDM4E | |
| SCHEMBL14269365 | 0.68 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1POLBKDM4E | |
| SCHEMBL4859042 | 0.63 | MAPK14 (0.53) | — | |
| SCHEMBL27561304 | 0.63 | MAPK14 (0.38) | SCN9ANPC1ALDH1A1FKBP1AKDM4E | |
| SCHEMBL4857310 | 0.62 | MAPK8 (0.56) | KDM4ELMNA | |
| SCHEMBL4852539 | 0.62 | MEN1 (0.49) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL4857845 | 0.61 | MEN1 (0.48) | NPC1RAB9AALDH1A1KDM4ELMNA | |
| SCHEMBL4850980 | 0.60 | MAPK8 (0.50) | SCN9ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849627-B2 | Including interleukin-1 and Tumor Necrosis Factor; treating rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, septic shock, cardiopulmonary dysfunction, acute respiratory disease, and cachexia | THE PROCTER & GAMBLE COMPANY (US) | 2005-02-01 | — | — | US | disclosed |