Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4850980 | 0.87 | MAPK8 (0.50) | MAPK8TSHRTDP1HPGDSP2RX3 | |
| SCHEMBL17591033 | 0.85 | P2RX3 (0.55) | MAPK8KDM4EKDM5AJMJD1CKDM3A | |
| SCHEMBL29826782 | 0.85 | P2RX3 (0.55) | MAPK8KDM4EKDM5AJMJD1CKDM3A | |
| SCHEMBL8456373 | 0.84 | MAPK8 (0.48) | MAPK8LMNATDP1LOXL2PIK3CA | |
| SCHEMBL4859054 | 0.84 | TDP1 (0.51) | MAPK8KDM4ETDP1HPGDSP2RX3 | |
| SCHEMBL8721822 | 0.80 | MAPT (0.50) | KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL7206668 | 0.78 | MAPT (0.44) | MAPK8L3MBTL1TSHRMCL1LOXL2 | |
| SCHEMBL24922618 | 0.77 | ESR1 (0.41) | MAPK8KDM4EKDM5AJMJD1CKDM3A | |
| SCHEMBL2015751 | 0.77 | LMNA (0.53) | KDM4EKDM5AJMJD1CKDM3ALMNA | |
| SCHEMBL14747021 | 0.76 | MAPK8 (0.42) | MAPK8KDM4ELMNAHPGDSLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210292340-A1 | CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2021-09-23 | — | — | US | disclosed |
| EP-3816163-A1 | CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) | 2021-05-05 | — | — | EP | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1427728-B1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | PROCTER & GAMBLE (US) | 2007-03-07 | — | — | EP | disclosed |
| US-7087615-B2 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1427732-A1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO 1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY | 2004-05-06 | — | — | US | disclosed |
| US-6730668-B2 | PREVENTING EXTRACELLULAR RELEASE | THE PROCTER & GAMBLE COMPANY | 2004-05-04 | — | — | US | disclosed |
| WO-2004026878-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2004-03-25 | — | — | US | disclosed |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2004-02-26 | — | — | US | disclosed |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-07-17 | — | — | US | disclosed |
| US-6566357-B1 | To inhibit the extracellular release of inflammatory cytokines; therapy | THE PROCTER & GAMBLE CO. | 2003-05-20 | — | — | US | disclosed |
| WO-2003024973-A1 | SPIROCYCLIC-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
| WO-2003024971-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | OPRK1, OPRD1, IL1B | MAPK8 1862/4885KDM4E 3622/4885KDM5A 3072/4885 |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL1A, IL6 | MAPK8 1960/4885KDM4E 3537/4885KDM5A 2760/4885 |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | IL6, IL1A, IL1B | MAPK8 677/4885KDM4E 4469/4885KDM5A 3471/4885 |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL6, IL1A | MAPK8 1333/4885KDM4E 3660/4885KDM5A 3278/4885 |
| US-20210292340-A1 | CELL NECROSIS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | LITAF, RIPK1, RIPK2 | MAPK8 117/4885KDM4E 4473/4885KDM5A 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.