Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851295 | 0.87 | MAPK14 (0.40) | MAPK14MAPTCPT1ALMNAALOX15 | |
| SCHEMBL27537569 | 0.84 | MAPK14 (0.41) | MAPK14MAPTFKBP1AKDM4ECPT1A | |
| SCHEMBL4856626 | 0.77 | MEN1 (0.55) | MAPTFAAHMEN1KMT2A | |
| SCHEMBL6334129 | 0.76 | CPT1A (0.36) | FKBP1AKDM4ECPT1ALMNA | |
| SCHEMBL27561304 | 0.75 | MAPK14 (0.38) | MAPK14MAPTFKBP1AKDM4ECYP19A1 | |
| SCHEMBL4852448 | 0.72 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL14269365 | 0.68 | ALDH1A1 (0.44) | KDM4EHSD17B10FAAHMEN1KMT2A | |
| SCHEMBL4850650 | 0.67 | USP2 (0.36) | MAPK14MAPTKDM4ELMNA | |
| SCHEMBL4859291 | 0.67 | USP2 (0.39) | MAPK14MAPTKDM4ELMNA | |
| SCHEMBL4850729 | 0.67 | ALDH1A1 (0.44) | MAPTFKBP1ACYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1427728-B1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | PROCTER & GAMBLE (US) | 2007-03-07 | — | — | EP | disclosed |
| US-7087615-B2 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| US-20050282844-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2005-12-22 | — | — | US | disclosed |
| US-6960593-B2 | 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1539761-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A] PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6849627-B2 | Including interleukin-1 and Tumor Necrosis Factor; treating rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, septic shock, cardiopulmonary dysfunction, acute respiratory disease, and cachexia | THE PROCTER & GAMBLE COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| EP-1427728-A1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY | 2004-05-06 | — | — | US | disclosed |
| US-6730668-B2 | PREVENTING EXTRACELLULAR RELEASE | THE PROCTER & GAMBLE COMPANY | 2004-05-04 | — | — | US | disclosed |
| WO-2004026878-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2004-03-25 | — | — | US | disclosed |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2004-02-26 | — | — | US | disclosed |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-07-17 | — | — | US | disclosed |
| WO-2003024971-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | OPRK1, OPRD1, IL1B | MAPK14 1966/4885MAPT 4250/4885FKBP1A 1609/4885 |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL1A, IL6 | MAPK14 1253/4885MAPT 4191/4885FKBP1A 457/4885 |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | IL6, IL1A, IL1B | MAPK14 1721/4885MAPT 2860/4885FKBP1A 225/4885 |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL6, IL1A | MAPK14 1863/4885MAPT 4685/4885FKBP1A 1947/4885 |
| US-20050282844-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1A, IL6, IL1B | MAPK14 1278/4885MAPT 2372/4885FKBP1A 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.