Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.30 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.30 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6333427 | 0.86 | HTR2C (0.39) | PDK4 | |
| SCHEMBL6332995 | 0.84 | JAK1 (0.32) | TSHRLMNAPDK4CNR1USP30 | |
| SCHEMBL6330870 | 0.82 | GYS1 (0.36) | PDK4USP30EEDRBBP4SUZ12 | |
| SCHEMBL6335122 | 0.82 | TSHR (0.34) | TSHRLMNAALDH1A1OPRK1PDK4 | |
| SCHEMBL24700152 | 0.70 | GRM5 (0.42) | PDK4USP30 | |
| SCHEMBL21276535 | 0.69 | MAPK1 (0.39) | LMNAMAPTMEN1KMT2ANPSR1 | |
| SCHEMBL30639364 | 0.69 | HDAC1 (0.36) | LMNAALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL30639361 | 0.69 | HDAC1 (0.36) | LMNAALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL23868537 | 0.69 | GRM1 (0.45) | PDK4USP30 | |
| SCHEMBL6492320 | 0.67 | HTR1D (0.37) | PDK4CNR1BRD4JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |